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Replior eCOA/ePRO

Behavioral science driven eCOA/ePRO

Most eCOA/ePRO systems solved the paper problem. They never solved the motivation problem. As studies become longer and more demanding, participant engagement naturally declines – leading to avoidable dropout, missing data, and reduced statistical power.

Replior eCOA/ePRO combines two unique components: a proprietary behavioral doctrine for designing participant engagement throughout a study, and a platform that puts those principles into practice through intelligent engagement mechanics. Together they help improve adherence, retention, and data quality, with demonstrated retention of 99% at Week 28 versus an industry benchmark of approximately 80%.

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What makes our eCOA/ePRO unique

This is not just another eCOA/ePRO solution.
Replior eCOA/ePRO is built around a fundamentally different philosophy. Rather than simply digitizing questionnaires, it actively helps maintain participant motivation throughout the study.

The doctrine surfaces the participant’s altruistic intent to contribute. The system sustains it. Week after week the platform delivers those experiences automatically through personalized reminders, progress tracking, milestones and adaptive content.
The outcomes are measured, repeatable, and especially strong where commodity ePRO routinely fails.

Behavioral engagement mechanics

Every engagement feature is designed with one objective: helping participants stay engaged throughout demanding clinical trials. Visible progress builds investment that grows harder to walk away from. Milestones reconnect participants to their contribution. Messaging is calibrated to where the participant is in the protocol, not to a generic schedule.

Rather than relying on generic reminders, Replior adapts communication, celebrates progress and reinforces each participant’s contribution to the study.

Trophies, Badges and Milestones

Medals and badges mark passed milestones and completed activities, making accumulated investment tangible. The longer a participant has contributed, the more they stand to forfeit by disengaging.

Progress Tracking

Participants see time invested, tasks completed, milestones reached, and streaks maintained. Surfacing this data continuously is the mechanic that turns participation from effort into routine.

Smart Reminders

Study-specific messages calibrated to protocol milestones: onboarding, first weeks, mid-study fatigue points, dose-escalation phases, end-of-study. Push, email, and SMS. Hundreds of messages designed per study, not a generic reminder schedule.

Adaptive Video Content

Study-tailored video tracks for both low-compliance and high-compliance participants. Dedicated videos explain to lower-compliance participants what their participation means for the patient community. High-compliance participants receive recognition that affirms and reinforces the behaviour.

quotes
Introducing gamification with Replior has improved the satisfaction of our patients and therefore increased the robustness of the database.

Diego Herrera Egea

Director of Clinical Data & Digital Innovation Almirall

Read Success Story

Intuitive User Experience

Deliver an exceptional user experience with Replior eCOA/ePRO’s flexible and intuitive design, making it easy for participants to engage and for researchers to conduct trials effectively.

Designed for All Age Groups

Intuitive app helps participants perform the tasks expected from them.

Customizable Widgets

Tailor the app with widgets specific to your trial needs, such as a welcome video.

Native App

Available on iOS and Android or accessible from any web browsers.

Device Independence

Support for patients using their own smartphone or provisioned devices.

Multi-language Support

Accommodate over 40 languages, with additional languages available upon request.

Unique Voice Recording

Allow patients to use voice recordings as cognitive memory notes enhancing data accuracy.

High-Quality Data Collection

Capture higher-quality data while reducing participant burden through seamless digital endpoint integration, automated data collection and real-time insights.

Real-time Data Capture

Capture timely and accurate data with questionnaires and event scheduling.

Digital Endpoint Integration

Collect data from RaySense, ScratchSense, and other connected devices automatically.

Sophisticated Scoring

Automatically score questionnaires for instant feedback and actionable insights.

Advanced Calculations

Provide precise, customizable data analysis tailored for your study with JavaScript-based calculations.

Seamless API Integration

Connect easily with EDC systems and other study-specific vendor systems to streamline data workflows.

Simple Participant Management

Optimize participant management and ensure compliance with Replior eCOA/ePRO’s advanced grouping and scheduling features.

eConsent Integration

Simplify the consent process, ensuring compliance and easing participant onboarding.

Participant Grouping

Tailor events and questionnaires to specific groups, improving relevance and compliance.

Treatment Schedules

Provide comprehensive information and customizable schedules to ensure protocol adherence.

Logbooks and Diaries

Collect periodic or ad hoc data such as medication intake and blood pressure.

Tasks and Visits Management

Provide one-click access to tasks, visit schedules, and preparation instructions.

Management and Reporting Tools

Gain comprehensive oversight and actionable insights with Replior eCOA/ePRO’s management and reporting tools, enhancing study performance and ensuring compliance.

Study Dashboard

Gain real-time visibility into study performance. Identify trends and behavior patterns.

Multiple Export Options

Easily extract data, including audit logs, notifications, and questionnaire exports.

Customizable and Standard Reports

Generate reports tailored for your needs or choose from a range of standard options.

Complete Audit Trail

Maintain a comprehensive audit trail from data entry through all changes.

Monitor Compliance, Act Early

Access insights at the study, task, site, and participant levels, allowing early action on outliers at every stage.

Where it pays off most

The behavioral doctrine produces the largest retention delta exactly where commodity ePRO fails hardest: when motivation is most tested.

52-week+ protocols:

Where motivation decay is structural and reminder-based engagement collapses

High recall-bias risk:

Where subjective outcomes drive primary endpoints and engagement quality directly shapes data quality

Dose escalation and up-titration:

Where peak side effects meet peak uncertainty and the participant most needs a reason to stay

Phase III where Phase II flagged retention risk

The highest-cost moment to discover the same problem twice

Chronic, fluctuating conditions:

Where symptom variability reads to the participant as 'it isn't working'

Prevention and healthy-volunteer trials (vaccine, contraception, PrEP):

Where participants feel fine and the industry default is monetary compensation

Related Products

Device Provisioning

Set up devices only after getting participant consent.
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EDC

Quick to build, easy to use. 

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Virtual Visits

Initiate participant remote visits directly from Replior eCOA/ePRO.
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Digital Endpoints

Integrate sensors that automatically connect to Replior eCOA/ePRO.
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FAQ

We deliver systems and make them available within 14 days. Express requests can be addressed on short notice with hours or a few days delivery time.
Yes, Replior eCOA/ePRO complies with all relevant regulations, including the EMA Guideline on computerized systems and electronic data in clinical trials (EMA/INS/GCP/112288/2023), ICH E6 (R3) Good Clinical Practice, FDA Guidance on Electronic Systems, Records, and Signatures, and EudraLex Volume 4 Annex 11 on Computerized Systems. Our system ensures robust data security and regulatory compliance.
Replior eCOA/ePRO integrates with various EDC systems, Randomization and Trial Supply Management (RTSM) systems, and other study-specific vendor systems through APIs. This ensures comprehensive data collection and streamlined workflows, reducing manual data entry and potential errors.
Yes, Replior eCOA/ePRO is highly customizable. You can tailor features such as questionnaires, treatment schedules, notifications, and reminders to meet the specific needs of your study. This flexibility ensures the system aligns perfectly with your trial protocols.
Replior eCOA/ePRO is compatible with iOS and Android devices through a native app, and accessible via any web browser on desktop computers. The system supports both patients using their own device and provisioned devices, offering flexibility and convenience for participants.
Yes, Replior eCOA/ePROsupports a wide range of languages.

Western and Northern European Languages:

  • English (UK)
  • Spanish
  • German
  • German (Austria)
  • German (Switzerland)
  • French
  • French (Switzerland)
  • Belgian French
  • French (Italy)
  • Portuguese
  • Italian
  • Dutch
  • Flemish
  • Swedish
  • Danish
  • Norwegian
  • Finnish

North American Languages:

  • English (US)
  • Spanish (US)

Eastern and Central European Languages:

  • Czech
  • Hungarian
  • Polish
  • Romanian
  • Russian
  • Ukrainian

South and Southeast Asian Languages:

  • Hindi
  • Marathi
  • Gujarati
  • Bengali
  • Telugu
  • Tamil
  • Kannada
  • Malayalam
  • Malay
  • Chinese

Additional languages can be added upon request, making it suitable for global clinical trials so participants can interact in their preferred language.

Replior eCOA/ePRO features a fully responsive design that works seamlessly on desktops, laptops, tablets, and smartphones. The intuitive and user-friendly interface ensures high compliance and retention rates among participants, making it easy for both researchers and participants to use.
Replior eCOA/ePRO integrates data from wearable technology and remote monitoring devices in real time. Specific study widgets in the app can display relevant data from wearables to participants, improving data collection and patient monitoring. This integration supports continuous and accurate data flow throughout the trial.
Replior eCOA/ePRO is built around a behavioral doctrine, not just software features. It has two parts: a proprietary framework that defines how to design trial touchpoints for retention and adherence, and the platform that operationalises it. Standard ePRO digitizes the paper diary. Replior’s approach addresses the motivation problem that causes dropout in long and demanding studies. The results are measurable: 99% Week 28 retention versus a roughly 80% benchmark in comparable studies.

Ready to improve participant retention?

Book a Demo

Ready to improve participant retention?

Book a Demo