Behavioral Science as Data Management Innovation

How Gamification Improves Retention and Data Integrity

Patient retention is one of the biggest threats to clinical trial success. When ePRO entries are late or missing, timelines slip, costs rise, and confidence in the dataset drops. The challenge is not only about technology. It is about how studies support the people behind the data.

Innovation in data management means building studies that patients can follow and sites can rely on. Applying behavioral science through gamification is a proven way. Embedding this design directly into ePRO helps sponsors increase adherence, improve on-time entries, and produce more dependable results.

Why behavioral principles belong in ePRO

Gamification does not turn clinical trials into games. It draws on behavioral principles – progress, purpose, responsibility, and feedback – to guide daily study tasks.

That looks like:

  • Scheduled videos that engage participant in the study for the right reasons
  • Messages and videos based on compliance level that nudges the participant to take action
  • Progress bars that show patients their effort counts
  • Encouraging notifications that educates and keep participants informed about the study
  • Tailored reminders in reliable channels that reduce missed entries without adding to site workload
  • Awards and badges when hitting their milestones

This approach works. In studies using Replior’s platform, diary compliance reached 94%, and participation held at 99%, including older patient populations. For clinical operations, that means fewer dropouts and smoother timelines. For data managers, it means more complete datasets, fewer queries, and stronger database readiness.

And in some studies, gamified ePRO is paired with passive measures such as UV or scratch sensors, which capture additional behaviors without adding burden for patients or sites.

Replior CEO Christer Nilsson will present at the 3rd Annual Clinical Data Management Innovation (CDMI) conference,
September 17–18 in Princeton, NJ.

Keynote: “Gamification in Clinical Trials: A Proven Path to Better Engagement, Retention, and Data Integrity”

📅 Sept 17, 12:00 PM

If patient participation and data quality are on your 2025 agenda, this is the session to mark. You will hear:

  • The science. The behavioral foundations that make gamification effective
  • The results. Case studies showing improved compliance and participation
  • Implementation. Practical steps for incorporating gamification into protocols
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🎤 Add the keynote to your calendar

See it in action at Booth 2

At Booth 2, you will see how Replior embeds behavioral science into ePRO to keep patients engaged. We will also show how Replior UV and scratch sensors complement ePRO by capturing additional behaviors without adding burden for patients.

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Meet the Replior Team

Replior at EADV 2025 & CDMI US 2025
Innovation Through Wearable Sensors & Behavioral Science

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